Branched KLVFF Tetramers Strongly Potentiate Inhibition of β-Amyloid Aggregation
نویسندگان
چکیده
منابع مشابه
Branched KLVFF tetramers strongly potentiate inhibition of beta-amyloid aggregation.
The key pathogenic event in the onset of Alzheimer's disease (AD) is the aggregation of beta-amyloid (Abeta) peptides into toxic aggregates. Molecules that interfere with this process might act as therapeutic agents for the treatment of AD. The amino acid residues 16-20 (KLVFF) are known to be essential for the aggregation of Abeta. In this study, we have used a first-generation dendrimer as a ...
متن کاملMechanisms of transthyretin inhibition of β-amyloid aggregation in vitro.
Tissue-specific overexpression of the human systemic amyloid precursor transthyretin (TTR) ameliorates Alzheimer's disease (AD) phenotypes in APP23 mice. TTR-β-amyloid (Aβ) complexes have been isolated from APP23 and some human AD brains. We now show that substoichiometric concentrations of TTR tetramers suppress Aβ aggregation in vitro via an interaction between the thyroxine binding pocket of...
متن کاملGraphene quantum dots for the inhibition of β amyloid aggregation.
The aggregation of Aβ peptides is a crucial factor leading to Alzheimer's disease (AD). Inhibiting the Aβ peptide aggregation has become one of the most essential strategies to treat AD. In this work, efficient and low-cytotoxicity inhibitors, graphene quantum dots (GQDs) are reported for their application in inhibiting the aggregation of Aβ peptides. Compared to other carbon materials, the low...
متن کاملInhibition of Alzheimer amyloid β aggregation by polyvalent trehalose.
A glycopolymer carrying trehalose was found to suppress the formation of amyloid fibrils from the amyloid β peptide (1-42) (Aβ), as evaluated by thioflavin T assay and atomic force microscopy. Glycopolymers carrying sugar alcohols also changed the aggregation properties of Aβ, and the inhibitory effect depended on the type of sugar and alkyl side chain. Neutralization activity was confirmed by ...
متن کاملPhotodynamic micelles for amyloid β degradation and aggregation inhibition.
Polymeric micelles loaded with chlorin e6 and Tanshinone I (TAS) were prepared and employed for photodegrading amyloid β (Aβ) aggregates and inhibiting Aβ fibrillation.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ChemBioChem
سال: 2007
ISSN: 1439-4227,1439-7633
DOI: 10.1002/cbic.200700338